Two Forms of Radiosurgery for Brain Metastases Are Equally Effective

Two Forms of Radiosurgery for Brain Metastases Are Equally Effective

By The ASCO Post
Key Points

  • The Gamma Knife was slightly more effective than RapidArc at focusing the beam of radiation, thus limiting spread to normal tissue.
  • RapidArc offered much quicker treatment compared to the Gamma Knife; Gamma Knife treatment usually took 60–100 minutes, about 3–5 times longer than RapidArc.Their study, published by Liu et al in Frontiers in Oncology, compared the two different devices in brain radiosurgery. Six patients, each with three or four brain metastases, were studied.Let us also remind ourselves sometime radiotherapy is synergistical., Furthermore attenuated viral payload prompting cancer dies to not spread and multiple others past the drawing board is gaining in speed of bench finding to clinical trial is getting more rapid We are learning with every trial and early phase 3 trial We do not know quite what we need to do to fast track to meaningful groups on but international consortia and brain cancer centers such as the 20 at Stanford’s integrated Brain cancer team– but we are nearThe Gamma Knife was slightly more effective than RapidArc at focusing the beam of radiation, thus limiting spread to normal tissue, and RapidArc offered much quicker treatment compared to the Gamma Knife, researchers said. Gamma Knife treatment usually took 60 to 100 minutes, about 3 to 5 times longer than RapidArc.Understanding the benefits of advanced radiosurgery technology is essential because there has been, and will continue to be, an increase in cases of brain metastases, said coauthor Adam Dicker, MD, PhD, Chair and Professor of Radiation Oncology, Pharmacology, and Experimental Therapeutics at the Sidney Kimmel Medical College at Thomas Jefferson University.“As drug therapy for cancer becomes better at controlling systemic cancer, disease in the brain increases over time. The brain is a sanctuary for cancer—chemotherapies and targeted agents can’t reach the brain and the central nervous system because of the blood-brain barrier,” Dr. Dicker said. “The results are that a number of different cancers are now showing up in the brain.”RapidArc radiation is a type of linear accelerator that emits high-energy photons. Very small beams with varying intensities are aimed at a tumor and then rotated around the patient. This results in attacking the target in a complete three-dimensional manner. A single treatment can take as little as 10 to 15 minutes.
  • Radiosurgery delivers a focused dose of radiation on tumors in order to shrink or kill the cancer, while sparing normal brain tissue. The Gamma Knife, invented in Sweden, features a circular array of 201 beams of gamma radiation that meet at a single point. The downside of the treatment, which is very accurate, is that patients wear a helmet that is fixed to the skull, Dr. Shi said. The procedure can also take a long time, he added.
  • Study Background
  • “In the end, using one or the other doesn’t make a significant clinical difference and that is important to know because physicians and patients now know they have a choice of treatments,” said Associate Professor Wenyin Shi, MD, PhD, Codirector of the Jefferson Brain Tumor Program.
  • Key Findings
  • While two advanced radio surgery approaches—Gamma Knife and RapidArc—offer different strengths, they are equally effective at eradicating cancer in the brain, say researchers at Sidney Kimmel Cancer Center at Jefferson.
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