Age at Primary Breast Cancer and Contralateral Cancer Risk in BRCA1/2 Carriers

Age at Primary Breast Cancer and Contralateral Cancer Risk in BRCA1/2 Carriers

Journal of Clinical Oncology

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  • The authors evaluated 6294 patients with invasive breast cancer, with and without BRCA1/2 mutations, treated between 1970 and 2003 and diagnosed at age <50 years to determine risks for contralateral breast cancer (CBC). Median follow-up was 12.5 years. Compared with non-BRCA carriers, CBC risk was higher for both BRCA1 (HR,(risk ) 3.31; P < .001) and BRCA2 (HR, 2.17; P = .01) mutation carriers. Cumulative 10-year CBC risk was 5.1% for non-BRCA carriers, 21.1% for BRCA1, and 10.8% for BRCA2. For BRCA1/2 carriers, but not for non-carriers, age at diagnosis of the first breast cancer was a significant predictor for CBC risk. BRCA1/2 carriers first diagnosed at age <41 years had a higher 10-year cumulative CBC risk (23.9%) compared with those diagnosed between 41 and 49 years of age (12.6%).
  • In patients with BRCA1/2 mutations, age at first diagnosis of breast cancer is a significant predictor for CBC risk.

Purpose

Impact of Age at Primary Breast Cancer on Contralateral Breast Cancer Risk in BRCA1/2 Mutation Carriers

J. Clin. Oncol 2015 Dec 23;[EPub Ahead of Print], AJ van den Broek, LJ vant Veer, MJ Hooning, S Cornelissen, A Broeks, EJ Rutgers, VTHBM Smit, CJ Cornelisse, M van Beek, ML Janssen-Heijnen, C Seynaeve, PJ Westenend, JJ Jobsen, S Siesling, RAEM Tollenaar, FE van Leeuwen, MK Schmidt

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