Colorectal Cancer Risk Varies Based on Latino Subgroup Affiliation

Colorectal Cancer Risk Varies Based on Latino Subgroup Affiliation

By The ASCO Post
AS DISCUSSED ON MY WEBSITE BOOK AND 40 MINUTES KUNM RADIO INTERVIEW

Key Points:

  • The researchers found Latinos from Mexico have the lowest chance of getting colorectal cancer compared to other Latino subgroups but had a higher rate of rectal cancer (35%) than other Latino subgroups.
  • More Mexicans (20%) and Central or South Americans (20%) were diagnosed with colorectal cancer before age 50 compared to other Latino subgroups.
  • Among Latinos in California, Cuban colorectal cancer patients had the highest proportion of deaths (63%), followed by Puerto Ricans (58%).

In the first study of its kind, University of Southern California (USC) researchers have found that colorectal cancer risk in Californian Latinos varies widely depending on the country of origin. Their study was published by Stern et al in Cancer Causes & Control.

“Hispanics are a very heterogeneous population, which is not really recognized in most cancer studies,” said Mariana Stern, PhD, a cancer epidemiologist and Associate Professor of Preventive Medicine at the Keck School of Medicine of USC. “Their risk factors might be different; their clinical characteristics could be different. We have to zoom into these observations and understand these disparities, because they may affect how patients are educated about the disease and how they are treated by doctors.”

USC researchers used California Cancer Registry data. They examined the profiles of 36,133 Latinos and 174,710 whites who were diagnosed with colorectal cancer between 1995 and 2011. Latinos were further identified by their country of origin: Mexico, Cuba, Puerto Rico, Central or South America, or not specified. USC researchers hope to pave the road toward personalized cancer care.

“Nowadays, most of the information we have on the molecular characteristics of colorectal cancer comes from the white population,” said Dr. Stern. “There is little information specific to Latinos. Plus, they are typically clumped as a group.”

Study Findings

The researchers found Latinos from Mexico have the lowest chance of getting colorectal cancer compared to other Latino subgroups. More Mexicans (20%) and Central or South Americans (20%) were diagnosed with colorectal cancer before age 50 compared to other Latino subgroups.

Among Latinos in California, Cuban colorectal cancer patients had the highest proportion of deaths (63%), followed by Puerto Ricans (58%).

Mexicans had a higher rate of rectal cancer (35%) than other Latino subgroups.

“We have pioneered surveillance of ethnic differences in cancer risk,” said Lihua Liu, PhD, Assistant Professor of Clinical Preventive Medicine at Keck Medicine of USC and a research scientist in the Los Angeles Cancer Surveillance Program. “We have previously shown dramatic differences in cancer risk among Asian subgroups. It’s time to also examine the heterogeneity within Latinos.”

However, hospitals and clinics in California do not have a standardized practice for collecting detailed ethnic and birthplace information, which resulted in a large proportion of Latino patients without country-of-origin information, posing a notable weakness of the study.

Standardizing ethnic and birthplace data collection will help guide future cancer control strategies, Dr. Liu said. The objective is to reduce the impact of cancer, the leading cause of death in the Latino community. In contrast, the top cause of death among whites is heart disease, followed by cancer.

Potential Key Factors

Genetics, varying degrees of intermixing, as well as acculturation to the U.S. lifestyle could all influence colorectal cancer incidence rates. For example, Latinos from the Caribbean generally have more African and fewer indigenous American forefathers. People from Mexico, however, have a larger proportion of indigenous American ancestry than Puerto Ricans or Cubans, Dr. Stern said.

“Maybe the biology of people from Mexico protects them from developing colorectal cancer,” she added. “This has been reported for breast cancer too. The heterogeneity of Latino populations presents a unique opportunity to disentangle the complex role of sociodemographics, culture, lifestyle, and genetics as potential determinants of colorectal cancer risk among Latinos and other populations

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