New Model Identifies Men With High-Risk Prostate Cancer

New Model Identifies Men With High-Risk Prostate Cancer

The Lancet Oncology
Prostate cancer in many , actually most can be very slow and highly responsive to hormonal manipulation if it cannot be removed surgically or treated with radiation. The latter two have significant impact on quality of life as we have talked before what if we put our heads together  and looked at things such as how angry were the ells under the microscope, age, blood psa level, prostate physical exam .The prostate-specific antigen (psa) test is used to screen for prostate cancer but has a high false-positive rate that translates into unnecessary prostate biopsies and over diagnosis of low-risk prostate cancers. We aimed to develop and validate a model to identify high-risk prostate cancer (with a gleason score of at least 7=angry cells picture under the scope) with better test characteristics than that provided by psa screening alone. The predefined sthlm3 model (a combination of plasma protein biomarkers [psa, free psa, intact psa, hk2, msmb, mic1], genetic polymorphisms [232 snps], and clinical variables [age, family, history, previous prostate biopsy, prostate exam]), and psa concentration were both tested in all participants enrolled. The primary aim was to increase the specificity compared with psa without decreasing the sensitivity to diagnose high-risk prostate cancer

 

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