The Most Effective Chemotherapy Regimen for Early-Stage Breast Cancer

The Most Effective Chemotherapy Regimen for Early-Stage Breast Cancer

JAMA Oncology
More than one regimen has been touted as being the best or , as good as any other in the treatment of early stage women wth breast cancer who stand to receive a benefit from chemotherapy combinations given adjuvantly( after the primary therapy of surgery) in hope of killing possibly and in some cases probably left beghind local and or systemic microscopic diessases as simply part of the personality of breast cancer. Many work  but toxicities vary, In this massive and elegant work on how to look back over data not done all at the same time by the same people or head to head- a so called retrospective metaanalysis, these authors beautifully controlled  for all those biases and idiosyncrasies and came up with 24 independent studies involving thousands of women and learned a lot- and yes, a probably winner arose in that although tied  for efficacy with others , its lesser toxicity  plus its high response rate show a probable best winner- at present. This is good science with big data Dr Ryan
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