Starving cancer cells of sugar could be the key to future treatment
I include this summary so one can see sensationalized rhetoric- common from ” across the pond ” claiming they understand the physiology of ALL tumor cells IN ALL CASES and in ALL conditions and have found a magi door or silver bullet. This article shows you being lead down that path. These are two not well known researchers making almost outrageous conclusion when they should possibly be commended for raising interesting questions to the international scientific community and of course encourage duplication of all their bench work. Then, pending what questions arise and I assure you they will as this horn about sugar and metabolic rates being the key has been blown before- it needs to be decided honestly ( IAM NOT IMPLYING ANY DISHONESTY- JUST OVER EXUBERANCE) if clinical trials -multi institutional and of what substance? based on what hard science are to be started Dr Ryan I am not holding my breath on this one although I want a “simple answer” as much as anyone I really doubt there is a truly unifying hypothesis such as the one presenting which is so easily and almost Disney PhD like in how it was reasoned through to and found. I promise to be first in line with any apology Dr Ryan
All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. NOTE This process call apoptosis is very complex, varies between all our normal cells as well as cancer cells. Great research is being done into how to manipulate this process to the benfi of the patents immune cells Dr Ryan This “programmed cell death” is a natural and essential part of our wellbeing. Every day, billions of cells die like this in order for the whole organism to continue functioning as it is supposed to.
But as with any programme, errors can occur and injured cells that are supposed to die continue to grow and divide. These damaged cells can eventually become malignant and generate tumours. BUT this is NOT the only mechanism of malignant clone development and sustenance DR Ryan In order to avoid their programmed cell death in this way, cancer cells reorganise their metabolism so they can cheat death and proliferate indefinitely. SOME DO SOME DO NOT IN ANY EFFECTIVE MANNER AND WITHIN SOLID TUMORS YOU CANHAVE A MIX Dr Ryan
Cancer researchers have known for decades that tumours use a faster metabolism compared to normal cells in our body. THIS IS NOT ALWAYS TRUE AT ALL DR RYAN Some simply keep growing and fending off or avoiding immune attack or chemotherapeutic attack but are not ” Faster” Dr Ryan One classic example of this is that cancer cells increase their consumption of glucose to fuel their rapid growth and strike against programmed cell death. This means that limiting glucose consumption in cancer cells is becoming an attractive tool for cancer treatments. BIG JUMP here NOT so simple DR
A new hope?
You may have seen articles or websites advocating that starving patients of sugar is crucial for getting rid of tumours or that eating less sugar reduces the risk of cancer. The story is not that simple. AND NOT TRUE Cancer cells always find alternatives NO sometimes they DIE to fuel their tank of glucose, no matter how little sugar we ingest. There is not a direct connection between eating sugar and getting cancer and it is always advisable to talk to your doctor if you have doubt about your diet.
Researchers have demonstrated that cancer cells use glucose to generate the building blocks of the cellular compounds needed for rapid tumour growth TRUE TO SOME DEGREE BUT NOT THE WHOLE STORY OF HOW THEY ARE ABLE TO GROW AND SPREAD. They also use it to generate molecules that guard against the toxic accumulation of reactive oxygen species, the cell-damaging molecules that activate programmed cell death. PARTLY TRUE BUT DO NOT START SUCKING DOWN SO CALLED ANTIOXIDANTS This means that glucose serves as a master protector against cell death. ANOTHER BIG LEAP
If the amount of sugar we eat doesn’t affect this process, the question we need to answer is how the cancer cells are instructed to consume more glucose. Who is filling the fuel tank? We have discovered that what allows tumours to evade their natural cause of death in this way is a protein that is overproduced in virtually every human cancer but not in normal cells. NEEDS CORROBORATION AND PROOF OF CAUSALITY AND TRUE LINKAGE
In a recent study published in Nature Communications we showed that cancer cells stimulate the over-production of the protein known as PARP14, enabling them to use glucose to turbocharge their growth and override the natural check of cell death. Using a combination of genetic and molecular biology approaches, we have also demonstrated that inhibiting or reducing levels of PARP14 in cancer cells starves them to death. AND THEIR CORROBORATING LABS ARE WHO? WHERE?
The best news is that by comparing cancer tissues (biopsies) from patients that has survived cancer and those that have died, we have found that levels of PARP14 were significantly higher in those patients that have died. THAT MAY MEAN NOTHING This means that levels of PARP14 in cancer tissues could also predict how aggressive the cancer would be and what the chances are of a patient’s survival. NO CLINICAL TRIAL HAS ESTABLISHED THIS
This means that a treatment which could block the protein could represent a significant revolution in the future of cancer treatment. AGAIN BIG LEAP What’s more, unlike traditional chemotherapy and radiotherapy, the use of PARP14 inhibitors would only kill cancer cells and not healthy ones. HUGE LEAP THAT THEY THINK THEY FOUND THE MAGIC BULLET The next step is to design and generate new drugs that can block this protein and work out how to use them safely in patients. NO THE NEXT STEP IS TO CORROBORATE IN INDEPNEDENT UNIVERSITY LABS WHAT NEEDS CORROBORATION AND IF THIER IS A SUGGESTION OF SOME ROLE OF PARP 14 TO HAVE MULTI INSITUTIONAL DEVELOPEMENT OF SMARTLY DESIGNED CLINICAL TRIALS ASKING THE RIGHT QUESTIONS AND MOT MISSING THE IMPORTAN LESSONS