Genetic Differences Between Primary Breast Cancer Among Black and White Women
Genetic Differences Between Primary Breast Cancer Among Black and White Women Journal of Clinical Oncology
In this study, the authors used exome sequencing and gene expression data in white and black women with stage I–III breast cancer to compare the racial distribution of tumor genomic characteristics and breast cancer recurrence. Compared with white women, black women harbored more TP53 mutations, fewer PIK3CA mutations, more intra-tumor genetic heterogeneity, and more basal tumors. Black women were at a higher risk of recurrence than white women. And this is consistently seen Dr Ryan
Tumors in black women had more aggressive tumor biology than those in white women, possibly contributing to the differences in breast cancer outcomes observed between the two racial groups.