August 10, 2015

Scientists Spot What Keeps Moles From Becoming Melanomas THIS IS HUGE

Protein that suppresses tumor puts brakes on further cell division. The importance of this far transcends beyond melanoma, although it is a great find and especially so for checking suspicious lesions  and for those with the dysplastic nevus syndrome who are at risk lifelong for conversion of angry moles into melanoma. Think for a moment, what if this protein is one of  a class of proteins that “put the brakes” on other cancers, what if it ,  per se, can put the brakes on other cancers or cancers  already spreading – think of the spinoff science to be learned and exploited. Dr Ryan

Scientists Spot What Keeps Moles From Becoming Melanomas

FRIDAY, Aug. 7, 2015 (HealthDay News) — A major genetic factor that prevents moles from turning into deadly melanoma skin cancer has been pinpointed by researchers.

It’s long been known that a mutation in the BRAF gene causes moles to start growing, but it wasn’t understood why they stop growing.

“The BRAF mutation that stimulates the initial growth of moles also stimulates the production of a tumor suppressor protein, p15, which ultimately acts as a powerful brake on further cell division,” study senior author Dr. Todd Ridky, an assistant professor of dermatology at the University of Pennsylvania, explained in a university news release.

“It’s this cell division that ultimately allows the transition from a normal mole into melanoma. When mole cells lose the p15 brake, cells can start dividing again and can progress into cancer,” he explained.

The study was published online recently in the journal Cancer Discovery.

The researchers plan to use this new insight to learn more about how melanoma develops and to try to develop new treatments. They’ll also study p15’s possible roles in other cancers.

More information

The American Cancer Society has more about melanoma.

SOURCE: University of Pennsylvania, news release, Aug. 5, 2015


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s